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Trapped in a lethal game, Sherlock is forced by his sister Eurus to choose between killing his best friend John or his brother Mycroft. Mycroft intentionally insults John to make himself the easier target, leading to a tense standoff where the brothers' complex bond and past mistakes are laid bare.

Sherlock Holmes reveals himself to a grieving John Watson by posing as a waiter during John's marriage proposal. The initial shock of seeing his supposedly dead friend quickly turns from disbelief to explosive fury as John realizes the extent of the deception.

Sherlock Holmes and Dr. John Watson meet for the first time in a hospital lab. Sherlock immediately displays his extraordinary powers of deduction by revealing intimate details of John's life, concluding with an invitation to view a flat together at 221B Baker Street.